When nasopharyngeal epithelial cells are infected by EB virus, presence of Rta induces cell division and nasopharyngeal carcinoma begins to develop. Professor Hu Huaizhong further proved that a large number of Rta protein produced in cells would inevitably arouse vigilance of the body's immune system. Then the immune system produced the corresponding antibodies in blood. Therefore, detecting the antibody concentration or content of Rta was a sensitive and specific diagnosis method for nasopharyngeal cancer.
Even at the very early stage of nasopharyngeal carcinoma, Rta can alert the patients. Rta has a excellent clinical value in the screening and the diagnosis of nasopharyngeal carcinoma since it can enhance the survival rate of nasopharyngeal cancer patients by early treatment. In recent years there have been many clinical trials and evidence showed that detecting human antibody of Rta by using the enzyme-linked immunosorbent assay (ELISA) technology for diagnosis of nasopharyngeal carcinoma has very high sensitivity and specificity.